A Completely Safe, Non-Drug,
Natural Approach
to Inflammation and Edema (Swelling)
Flavay® has been licensed and sold in France for reducing
inflammation and edema (swelling) since 1950 and is now available
in the United States as a dietary supplement. Research shows
several ways that Flavay® can stimulate the immune response
to help normalize the balance of chemicals in the body that
control pain and inflammation.
Naturally Inhibit Inflammation
Inflammation is caused by the overproduction of free radicals
in a specific area of the body. We now know that antioxidants
work together to defeat free radicals and inhibit the biological
pathway that triggers inflammation, and Flavay® is particularlyeffective as an anti-inflammatory.
Flavay® can selectively bind to the connective tissue
of joints, preventing inflammation and lessening pain. One of
the very first benefits observed and studied Dr. Jack Masquelier,
in as early as 1947, was the anti-inflammatory effect of Flavay®.
Research demonstrates that Flavay® inhibits the release
and synthesis of histamine (which produces accelerated blood
flow, dilates capillaries and increases their permeability,
thereby leaking plasma into surrounding tissue), a key factor
in the promotion of inflammation.
Studies demonstrate that the anti-histamine action of Flavay®
is obtained through inhibiting the activity of the enzyme histidine
decarboxylase. Dr. Masquelier’s research has been confirmed
by German studies which show that Flavay® may lower the
production of histamine with as much as 86% inhibition of histidine
decarboxylase.
Flavay® also neutralizes free radicals that promote swelling
and cause inflammation. A free radical called superoxide is
involved in the inflammation of arthritis. Flavay® readily
quenches the superoxide free radicals.
Edema (Swelling)
Edema is an uncomfortable condition and can be both painful
and dangerous. Swollen and painful legs and ankles, puffiness
of the eyes and an overall bloated look and feel are examples
of edema. It involves the leakage of blood serum into surrounding
tissues and Flavay® has shown that it can reduce this
leakage by strengthening capillary walls.
Italian scientists from the University of Florence studied
the effect of Flavay® on venous congestion (edema) in
the legs. The study involved 40 subjects consisting of 13 men
and 27 women between the ages of 34 and 74. The subjects were
randomly divided into two groups. One group received a placebo
and the other group received 300 mg of Flavay® daily for
60 days.
All of those taking the Flavay® had relief from at least
some of the symptoms. After 30 days, the pain was totally relieved
in in 38 percent of those taking Flavay®, the swelling
disappeared in 26 percent (the circumference of the legs was
measured above the ankle), and 11 percent experienced a decrease
in the feeling of heaviness in their lower limbs. After 60 days,
the pain was totally relieved in 67 percent of those taking
Flavay®, the swelling disappeared in 63 percent, and the
decrease in heaviness jumped to 33 percent.
Recovery from Sports Injuries
and Postoperative Inflammation
Research has shown that Flavay’s® ability to strengthen
vascular walls may help the body to repair injuries faster.
In an Australian study conducted on two groups of soccer players
that had sustained injuries, those that consumed Flavay®
for ten days following their injuries experienced significantly
less swelling than those who did not and, in some of those taking
Flavay®, the swelling had completely disappeared. Other
research has demonstrated the ways in which Flavay® may
actually inhibit inflammation including double-blind studies
conducted in France which showed that Flavay® can reduce
postoperative inflammation.
Nitric Oxide Toxicity and Chronic
Inflammation
Contemporary research shows that elevated levels of nitric
oxide (sometimes referred to as "NO") appear to contribute
to a number of seemingly different disorders that all have a
common element of abnormal immune or inflammatory responses.
Studies of arthritis, colitis, and other inflammatory disorders
have all demonstrated elevated levels of nitric oxide synthesis.
In the case of arthritis, nitric oxide has been implicated in
the destruction of the pericellular and extracellular matrix
of cartilage in arthritis.
Arthritis is an umbrella term for more than 100 different conditions
that produce either inflammation of connective tissue (joints
and tendons) or degeneration of the articular cartilage, a wearing
down of the protective covering that cushions the ends of bones,
allowing bones to rub together without causing damage to the
joints.
When joints become arthritic, they become inflamed and enlarged,
interfering with the normal flow of blood. For example, when
you bend an arthritic knee, you cut off blood flow to the area
which sets into motion of a chain of events that will lead to
a burst of free radicals when the blood flow returns (known
as "reperfusion injury"). When you release the knee,
a proliferation of free radicals causes the area to become even
more inflamed, contributing to the degeneration of the joint,
which becomes more swollen and worn down.
High levels of nitric oxide have also been implicated in the
inflammation that is associated with asthma. Asthmatics exhale
significantly higher levels of nitric oxide and type II nitric
oxide synthase (also known as "NOS") expression is
increased in biopsy specimens from asthmatics.
It's long been recognized that nitric oxide is essential for
normal blood circulation as it controls the muscular tone of
blood vessels and regulates circulation and blood flow. However,
excessive amounts of nitric oxide can be deadly to the cardiovascular
system and actually contribute to disease and inflammation.
High levels of nitric oxide can restrict blood flow and promote
production of more free radicals, including the dangerous peroxynitrate.
Flavay® can significantly scavenge nitric oxide radicals.
However, as we'll discuss next, your body needs a certain amount
of nitric oxide in order to maintain good health. Nitric oxide
is paradoxical. It can both mediate normal physiological functions
and it can be highly toxic. Nitric oxide can act as an anti-inflammatory
under normal health conditions, but it can have the opposite
effect and cause more inflammation to an already inflamed area
when overproduced. The key, therefore, is to maintain the optimum
balance of this double-edged sword, nitric oxide.
Flavay® and the Nitric
Oxide Connection
Nitric oxide is a colorless gas produced by many different
cells in the body that, depending on the situation, can be very
good or very bad. Nitric oxide plays several important
roles in the body:
Nitric oxide is an important signaling molecule that turns
genes on and off.
By controlling the muscular tone of blood vessels, nitric
oxide regulates the circulation and normalizes blood flow.
Nitric oxide modulates communication between brain cells
and is instrumental in helping us concentrate and learn
new information, and also in maintaining memory.
When produced by immune cells, nitric oxide fights infection,
kills tumor cells and promotes wound healing.
Nitric oxide is essential for perceiving pleasure and
pain, and it helps translate sexual excitement into penile
erections.
Nitric oxide aids in digestion of food by helping to control
gastric movements.
But nitric oxide can be very destructive under other circumstances:
Nitric oxide restricts blood flow.
When produced in excess by immune cells, nitric oxide
can trigger chronic inflammation, which can cause arthritis,
colitis, inflammatory bowel disease and possibly cancer.
Nitric oxide promotes production of more free radicals.
In the brain, nitric oxide can hamper mental function
and cause memory loss and brain aging.
The real trouble starts when nitric oxide encounters the superoxide
free radical and becomes peroxynitrate, which destroys antioxidants
like glutathione, vitamin E and common flavonoids, and damages
proteins in the body. As long as nitric oxide is produced in
the right amount, it remains friendly. But if nitric oxide is
overproduced, the effect can be very toxic. Research demonstrates
that Flavay® can help to maintain the optimal level of
nitric oxide by helping the body to produce adequate levels—and
to neutralize this free radical where it does harm.
Superior Antioxidant Support
Flavay® is superior to other antioxidants because its
protective effects are multiplied in the body. While it provides
its own, powerful antioxidant protection, it also supports the
dynamic interplay between other antioxidants in the body. Flavay's
ability to “recycle,” or regenerate vitamins C and
E after they have quenched free radicals vastly extends their
unique antioxidant powers, helping to maintain an optimal, synergistic
antioxidant balance in the body.
Flavay® is rapidly absorbed and very quickly distributed
throughout the body. As a free radical fighter, Flavay®
comes to the aid of the body more quickly than other antioxidants,
reducing the potential for free radical damage and the ravages
of aging. Flavay® also possesses more reactive sites for
neutralizing free radicals than other known antioxidants. Furthermore,
Flavay® permits reactivity with both positively and negatively
charged free radical species. What this means is that Flavay®
can “quench” or “scavenge” (neutralize)
a broad variety of free radicals. Highly reactive as an antioxidant
in both lipid (fat) and aqueous (water) phases, Flavay®
neutralizes oxygen free radicals and is a valuable protector
of healthy cells in a variety of internal conditions. This is
a unique property among antioxidants, as most work either in
lipid or aqueous phases, but not both. As a free radical scavenger,
Flavay® is like an antioxidant
prize fighter that can successfully take on all challengers,
big or small, in any kind of weather.
"Radical Scavenger Effect"
of Flavay®
Protected by U.S. Patent No. 4,698,360
Flavay® is the actual product—used in the experiments—by
which Dr. Jack Masquelier established and patented the "radical
scavenger effect."
"[A] method for preventing and fighting
the harmful biological effects of free radicals
in the organism of warm blooded animals and more especially
human beings, namely cerebral involution, hypoxia following
atherosclerosis, cardiac or cerebral infarction, tumour
promotion, inflammation, ischaemia, alterations
of the synovial liquid, collagen degradation,
among others. The method consists in administering to
said animals and especially to human beings an amount,
efficient against said effects, of a plant extract with
a proanthocyanidins content which has a radical
scavenger effect"—Dr. Jack Masquelier,
U.S. Patent No. 4,698,360.
Flavay’s® strong antioxidant power is patented—as
a scavenger of the free radicals that play a major
role in the degradation of collagen and the initiation, duration
and breakdown of inflammation. That means that your immune system
works better, your joints hurt less, and your blood flows better,
all because of Flavay®.
Statements made herein have not been
evaluated by the Food and Drug Administration. These products are not intended
to diagnose, treat, cure or prevent any disease.
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