A Completely Safe, Non-Drug,
Natural Approach
to Normalizing Immune Function
A strong immune system is the cornerstone of good health as
it protects your body against disease. There are several important
ways that Flavay® can nourish and invigorate your immune
system. First, Flavay® helps to normalize immune functions
at the cellular level. Flavay® prevents free radical damage
to macrophages, a type of white blood cell that generates nitric
oxide to destroy bacteria, viruses and parasites. However, if
nitric oxide is overproduced it turns on its host and damages
the macrophages—thereby impairing immune function. Thus,
phrases such as "double-edged sword" are frequently
applied to nitric oxide in health and disease. This emphasizes
the importance of another way that Flavay® benefits the
immune system: regulating nitric oxide in the body. Research
shows that Flavay® can help to maintain the optimal level
of this free radical by helping the body to produce adequate
levelsand to neutralize nitric oxide where it does harm.
Finally, by increasing the activity of vitamins C and E in
the body, Flavay® helps the body maintain its antioxidant
defenses, giving the immune system more ammunition to fight
infection.
How Your Immune System Works
Although it's called a "system," the immune system
is not associated with one particular organ but it's a collection
of cells that "speak" to one another—and with
the rest of the body— through chemical messengers (the
immunotransmitters) and thereby work in close harmony to protect
the body from the harmful effects of bacteria, viruses, parasites
and environmental toxins.
The most important components of the immune cells are the white
blood cells (lymphocytes), which include T-cells, B-cells and
macrophages. Macrophages are the immune system's foot soldiers,
capable of engaging in hand-to-hand combat as they literally
gobble up invaders to destroy them.
The white blood cells depend upon immunotransmitters called
"cytokines" to communicate with one another and to
coordinate their ferocious activity. Cytokines are to the immune
system what neurotransmitters are to the brain. Just as the
brain relies upon neurotransmitters to exchange information
among its neurons and with the rest of the body, so your immune
system depends upon cytokines.
When your body is threatened by an invasion, cytokines signal
your immune system to mobilize reserve troops of white blood
cells. When the invasion is over, your cytokines are responsible
for sending the signals to stop mobilizing the troops. In other
words, these immunotransmitters coordinate your white blood
cells, boosting their activity at times of infection, injury,
or other demands and reining them back in after battle.
Flavay® Normalizes Immune
Cell Functions and
Actually Boosts Immune Function
When the body fights off an infection, the cytokines go to
work, sending messages to the brain that cause more white blood
cells to mobilize. The more white blood cells your body activates,
the more free radicals they produce. These free radicals are
among your immune system's most powerful weapons, as a response
to injury and during times of disease, emotional stress and
aging. Research demonstrates that Flavay® has the power
to restore cytokine imbalances and can normalize white blood
cell activity, thereby boosting immune function.
Flavay® Scavenges the
Body's Terrorists: Rampaging Free Radicals
Free radicals are like pellets of poison that destroy invaders
by interfering with their cellular machinery, literally dissolving
or breaking down the genetic material of bacteria, toxins and
viruses.
When all is going well, the immune system is capable of identifying
foreign invaders such as viruses and bacteria by accurately
"reading" molecular codes found on cell surfaces.
These molecular codes are like flags of different armies, and
the immune system will not attack a cells if it "reads"
a flag belonging to the body's own host army. Unfortunately,
however, free radicals can interfere with the biological components
of our healthy cells, just as they destroy invaders. This leads
to many diseases.
When the immune system's cytokines activate macrophages (the
white blood cells capable of gobbling up invading viruses and
bacteria), the macrophages produce large amounts of nitric oxide
in the course of battle. Nitric oxide is a colorless gas produced
by many different cells in the body that, depending on the situation,
can be very good or very bad. Nitric oxide
plays several important roles in the body:
Nitric oxide is an important signaling molecule that turns
genes on and off.
By controlling the muscular tone of blood vessels, nitric
oxide regulates the circulation and normalizes blood flow.
Nitric oxide modulates communication between brain cells
and is instrumental in helping us concentrate and learn
new information, and also in maintaining memory.
When produced by immune cells, nitric oxide fights infection,
kills tumor cells and promotes wound healing.
Nitric oxide is essential for perceiving pleasure and
pain, and it helps translate sexual excitement into penile
erections.
Nitric oxide aids in digestion of food by helping to control
gastric movements.
But nitric oxide can be very destructive under other circumstances:
Nitric oxide restricts blood flow.
When produced in excess by immune cells, nitric oxide
can trigger chronic inflammation, which can cause arthritis,
colitis, inflammatory bowel disease and possibly cancer.
Nitric oxide promotes production of more free radicals.
In the brain, nitric oxide can hamper mental function
and cause memory loss and brain aging.
The real trouble starts when nitric oxide encounters the superoxide
free radical and becomes peroxynitrate, which destroys antioxidants
like glutathione, vitamin E and common flavonoids, and damages
proteins in the body. The good news is that Flavay® scavenges
peroxynitrate and has a remarkable modulatory effect on nitric
oxide—helping to maintain optimal levels in the body and
neutralizing this free radical where it does harm.
"Radical Scavenger Effect"
of Flavay®
Protected by U.S. Patent No. 4,698,360
Flavay® is the actual productused in the experimentsby
which Dr. Jack Masquelier established and patented the "radical
scavenger effect."
"[A] method for preventing and fighting
the harmful biological effects of free radicals
in the organism of warm blooded animals and more especially
human beings, namely cerebral involution, hypoxia following
atherosclerosis, cardiac or cerebral infarction, tumour
promotion, inflammation, ischaemia, alterations
of the synovial liquid, collagen degradation, among
others. The method consists in administering to said
animals and especially to human beings an amount, efficient
against said effects, of a plant extract with a proanthocyanidins
content which has a radical scavenger effect"Dr.
Jack Masquelier, U.S. Patent No. 4,698,360.
Flavay’s® strong antioxidant power is patented—as
a scavenger of the free radicals that play a major
role in the initiation, duration and breakdown of inflammation.
That means that your immune system works better, your joints
hurt less, and your blood flows better, all because of Flavay®.
Flavay Increases the Activity
of Vitamins C and E
Flavay® recycles and significantly extends the lifetime
of vitamin C and potentiates vitamin E, and thereby creates
a more powerful, synergistic antioxidant defense in the body.
This is important because vitamins C and E are key players in
the body's protective antioxidant army.
Antioxidants fight corrosive and destructive forces that constantly
work to break down our bodies. Overwhelming scientific evidence
demonstrates that those of us who eat a diet rich in antioxidants
and take antioxidant supplements will live longer and healthier
lives. Working as a defensive army, antioxidants work together
in the body to maintain our health and vigor by protecting us
from damage caused by rampaging free radicals which, like terrorists,
injure healthy cells and tissues.
Don't underestimate the threat that free radicals pose to our
health. Contemporary scientists now believe that free radicals
are causal factors in nearly every known disease, from heart
disease to arthritis to Parkinson's to Alzheimer's to ALS to
multiple sclerosis to cataracts to the aging process itself.
As a free radical fighter, Flavay® comes to the aid
of the body more quickly than other antioxidants, reducing the
potential for free radical damage and the ravages of aging.
Flavay® also possesses more reactive sites for neutralizing
free radicals than other known antioxidants. Furthermore, Flavay®
permits reactivity with both positively and negatively charged
free radical species. What this means is that Flavay®
can quench or scavenge (neutralize)
a broad variety of free radicals. Highly reactive as an antioxidant
in both lipid (fat) and aqueous (water) phases, Flavay®
neutralizes oxygen free radicals and is a valuable protector
of healthy cells in a variety of internal conditions. This is
a unique property among antioxidants, as most work either in
lipid or aqueous phases, but not both. As a free radical scavenger,
Flavay® is like an antioxidant prize fighter that can
successfully take on all challengers, big or small, in any kind
of weather.
Flavay®: More Than 50
Years of Protection
Now available in the United States, Flavay®
is the actual polyphenol that has been licensed and sold in
France since 1950. And, Flavay Plus®
utilizes the dynamic interplay between Flavay® and the
other antioxidant nutrients and their co-factors in order to
provide you and your family with the best that nutritional science
has to offer for immune protectionin a convenient, cost
effective capsule.
Statements made herein have not been
evaluated by the Food and Drug Administration. These products are not intended
to diagnose, treat, cure or prevent any disease.
Masquelier, J. Plant extract
with a proanthocyanidins content as a therapeutic agent having
radical scavenging effect and use thereof. U.S. Patent No. 4,698,360,
1987.
Masquelier, J. A lifetime devoted to OPC and Pycnogenols. Alfa
Omega Editrice, Pub., 1996.
Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice,
Publishers, 1995.
Lombard, J., Germano, C. The brain wellness plan: breakthrough
medical, nutritional and immune-boosting therapies to prevent
and treat: depression, Alzheimer's disease, chronic fatigue syndrome,
attention deficit disorder, multiple sclerosis, Parkinson's disease,
Lou Gehrig's disease. Kensington Pub. Corp., 1998.
Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats
Publishing, Inc., 1997.
Packer, L., et al. The antioxidant miracle: your complete plan.
John Wiley & Sons, Inc., 1999.
Packer, L., et al. Antioxidant food supplements in human health.
Academic Press, 1999.
Lincoln, J., Hoyle, C.H.V., Burnstock, G., Nitric oxide in health
and disease. Cambridge University Press, 1997.
Moncada, S., Nistico, G., Bagetta, G., Higgs, E.A. Nitric oxide
and the cell. Princeton University Press, 1998.
Facino, R.M., et al. Free radical scavenging action and anti-enzyme
activities of procyanidines from vitis vinifera. A mechanism for
their capillary protective action. Arzneimittelforschung, 44:
592-601, 1994.
Passwater, R.A. The antioxidants: the nutrients that guard your
body. Keats Publishing, Inc., 1985.
Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants.
Keats Publishing, Inc., 1995.
Facino RM, et al. Free radical scavenging action and anti-enzyme
activities of procyanidines from Vitis vinifera. A mechanism for
their capillary protective action. Arzneimittelforschung, 44:
592-601, 1994.
Kuttan R, et al. Collagen treated with catechin becomes resistant
to the action of mammalian collagenase. Experientia, 37: 221-223,
1981.
Masquelier, J., et al. Stabilization du collagene par les oligomeres
procyanidoliques. Acta Therapeutica, 7:101-105, 1981.
Masquelier, J. Aspects pharmacologiques nouveaux de certains flavonoides.
A Vie Medical 12:1969.
Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques
totaux du raisin. Acta Therapeutica, 4, 1978.
Laparra, J., et al. Etude pharmacocinetique des oligomeres flavonoliques.
Plantes med et phyto, Tome XI, pp. 133-142, 1977.
Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de laction
des oligomeres procyanidoliques sur des cellules mesenchymateuses
en culture. Ii lattachment des fibres elastiques aux cellules.
(Study of the effect of procyanidolic oligomers on mesenchymal
cells in culture. Ii attachment of elastic fibers to the cells.)
Pat Biol, (30)6:601-7, 1990.
Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular
and crystal structure of (+)-2,3-trans-3,4-trans-leucocyanidin
[(2r,3s,+r)-(+)-3,3, 4.4, 5.7-Hexahydroxyflavan]
dihydrate, and comparison of its heterocyclic ring conformation
in solution and the solid state. Journal of the Chemical Society;
Perkin Transactions I 1985. pp. 1413-17.
Masquelier, J. Proanthocyanidins et radicaux libres. 1985.
Uchida, S., et al. Condensed tannins scavenge active oxygen free
radicals. Med Sci Res, (15) 1987. pp. 831-832.
Ariga, T. Radical scavenging action and its mode in procyanidins
b-1 and b-3 from azuki beans to peroxyl radicals. Agric Biol Chem,
54(10) 1990. pp. 2499-2504.
Da Silva, R., et. al. Radical scavenger capacity of different
procyanidins from grape seeds. Presented at a symposium, Free
radicals in biotechnology and medicine. Royal Society Of
Chemistry, London January 1990, pp. 79-80.
Bauman, J., Wurm, G., Bruchhausen, F. Hemmung der prostagladinsynthetase
durch flavonoide und phenolderivate im vergleich nit deren 02
radikalfangereigenschaften Arch Pharm, (Weinheim) 313 (1980)
pp. 330-337.
Flesch M., et al., Effects of red and white wine on endothelium-dependent
vasorelaxation of rat aorta and human coronary arteries. Am J
Physiol 1998;275:1183-94.
Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM.
Isolation and characterization of endothelium-dependent vasorelaxing
compounds from grape seeds. J Agr & Food Chem In press.
Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation,
endothelium, and wine. BioFactors 1997;6:455-459.
Fitzpatrick, D.F., Hirschfield SL, Ricci T, Jantzen P, Coffey
RG. Endothelium-dependent vasorelaxation caused by various plant
extracts. J Cardiovasc Pharmacol 1995;26:90-95.
Fitzpatrick, D.F., Hirschfield SL, Coffey RG. Endothelium-dependent
vasorelaxing activity of wine and other grape products. Amer J
Physiol 1993;265:H774-H778.
Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with
catechin becomes resistant to the action of mammalian collagenase.
Experientia, 37: 221-223, 1981.
Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95:
89-97, 1990.
Tixier, J.M., et al. Evidence by in vivo and in vitro studies
that binding of pycnogenols to elastin affects its rate of degradation
by elastases. Biochem Pharmacol, 33: 3933-3939, 1984.
Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985.
Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers
extracted from vitus vinifera l. in the rat. European
Journal of Drug Metabolism and Pharmaccokinetics. 1978, No. 1
pp. 15-30.
Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging
activity of proanthocyanidolic oligomers encapsulated in glycospheres:
an in vivo and in vitro study. Cosmetology Department & S
Biovectors, Ramonville St. Agne France. pp. 1-9.
Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i
converting enzyme by flavanolic compounds: in vitro and in vivo
studies. Planta Medica, May 26, 1986. pp. 12-15.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-oedenme de la patte. Sanofi Res Toul Cedex
Fr, pp31-40.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-activite aniagoniste vis-a-vis des mediateurs
de linflamation. Sanofi Res Toul Cedex Fr, pp. 31-40.
Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire,
spontanement ou artificiellement diminuee par laction dune
substance capillaro-toxique chez des personnes agees--action benefique
dun agnet actif sur la micro-circulation: lEndotelon.
Inform. Therapeut. 1980. pp. 302-305.
Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude
dun microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7,
1990.
Lagrue, G., Olivier-Martin, F., Grillot, A. Etude des effets
des oligomeres du procyanidol sur las resistance capillaire dand
lhypertension arterielle et certaines nephropathies.
Sen. Hosp. Paris 18-25 Septembre, 1981.
Beylot, C., Bioulac, P. Essai therapeutique dun angioprotecteur
peripherique, lEndotelon. Actualite Therapeutique Gaz. Med.
de France (87)22:2919-24, 1980.
Lesbre, F.X., Tigaud, J.D. Effect de lEndotelon sur lindice
de fragilite capillaire dan une population specifique: les sujets
cirrhotiques. Gaz. Med. de France, (90)24 1983.
Sarrat, L. Abord therapeutique des troubles fonctionnels des membres
inferieurs par un microangioprotecteur lEndotelon. Bordeaux
Med, 11:685-8, 1981.
Delacroix, P. Etude en double aveugle de lEndotelon dans
linsuffisance veineuse chronique. Therapeutique, la Revue
de Medicine, (27-28) Sept. 1981. pp. 1793-1802.
Thebaut, J.F, Thebaut, P., Vin, F. Etude de lEndotelon dand
les manifestations fonctionnelles de linsuffisance veineuse
peripherique-resultats dune etude en double aveugle portant
sur 92 patients. Gazette Medicale, (92)1, 1985. pp. 96-100.
Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and
arachidonate metabolism in platelets by procyanidins. Prostagland
Leukotri Essent Fatty Acids, 38:181-8, 1989.
Masquelier, J. Pycnogenols: recent advances in the therapeutical
activity of procyanidins. Supplement of Planta Medica, Journal
of Medicinal Plant Research and Journal of Natural Products, July
1980 pp. 243-256.
Henning, B., et al. Lipid peroxidation and endothelial cell injury:
implications in atherosclerosis. Free Rad Path & Med, (4)1988
pp. 99-106.
Masquelier, J. Les procyanidols du vin leur role dans lalcoolisme.
pp. 88-93.
Gazave, J.M. Notions recentes sur les capillaires
unpub. bulletin from the Laboratoire De Physiologie Patholigie
pp. 26-29.
Ruf, J.C. Wine and polyphenols related to platelet aggregation
and atherothrombosis. Office International Vigne et du Vin, Nutrition
and Health Unit, Paris France; Drugs under Experimental and Clinical
Research (Switz.) 25/2-3 (125-131), 1999.
Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin.
Acta Physiologica Academiae Scientiarum Hungaricae, Tomus 56(2):235-240,
1980.
Tayau, M.F, LeFevre, G. Action du leucocyanidol sur lhyalaluronidase.
Bull Soc Pharm Bordeaux, 95:132-136, 1956.
Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie.
Essai Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22.
Henriet, J.P Une Etude Exemplaire Pour Un Phlebotrope: letude
EIVE. Unpub., pp. 77-83.
Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres
procyanidoliques dans la paroi des capillaires sanguins du poumon
decobaye. Acta Therapeutica (8) 1982. pp. 223-237.
Kuttan, R., Donnelly, P., Di Ferrante, N. Collagen treated
with (+) -catechin becomes resistant to the action of mammalian
collagenase. Laboratory of Connective Tissue Research, Dept.
of Biochem. Baylor Col. of Med., Houston TX. 28, May, 1980.
Gendre, P., Laparra, J., Barraud, E. Effect protecteur des
oligomeres procyanidoliques sur le lathyrisme experimental chez
le rat. Ann. Pharm. Francaises, (43)1, 1985 pp. 61-73.
Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal
circulation. Study of the effect of procyanidolic oligomer (Endotelon).
Jn. Fr. Opthalmol, (11)5:453-460, 1988.
Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and
dazzling: use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol
Fr, 88(2):173-4, 177-9, 1988.
Proto, F. et al. Electrophysical study of vitis vinifera procyanoside
oligomers effects on retinal function in myopic subjects. Ann
Ott Clin Ocul, 114:85-93, 1988.
Saracco, J.B., Estachy, G.M. Etude d lEndotelon en opthalmologie.
Gaz Med de France, 88:2035-2038, 1981.
Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies.
Klin Monatsbl Augenheilkd, 178:386-389, 1981.
Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol,
11:453, 1988.
Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C.
Bordeaux Medicale, (16)11. pp. 1467-74, 1978.
Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology.
Bull Soc Ophtalmol Fr. 87(12):1441-4, 1987.
Fromantin, M. Les oligomeres procyanidoliques dans le traitement
de la fragilite capillaire et de la retinopathie chez les diabetiques.
A propos de 26 cas. Med Int, 16(11):432-434, Nov. 1981.
Arne, J.L. Contribution a letude des oligomeres procyanidoliques:
Endotelon, dans la retinopathie diabetique (a propos de 30 observations).
Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982.
Baruch, J. Effect of Endotelon in postoperative edema. Results
of a double-blind study versus placebo in 32 female patients.
Ann Chir Plast Esthet 29(4):393-5, 1984.
Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism
in rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62,
1981.
Gabor, M. Pharmacologic effects of flavonoids on blood vessels.
Angiologica, 9:355-374, 1972.
Havsteen, B. Flavonoids, a class of natural products of high pharmacological
potency. Biochem Pharmacol, 32:1141-48, 1983.
Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer,
H.J. Berkhauser Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger.,
1977.
Masquelier, J. Action protectrice du vin sur lulcere gastrique.
Resultats, p. 61.
Amella, M., et al. Inhibition of mast cell histamine release by
flavonoids and bioflavonoids. Planta Medica, 5116-20, 1985.
Shaw, R. How [Australian] PycnoGenol [MASQUELIERs®]
Helps Sports People.
Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums
Cosmet Arom 95:89-97, 1990.
Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques
(Endotelon) dans le traitement des lymphoedemes post-therepeutiques
de members superieurs. Symposium Satellite, Congres International
dAngiologie, Toulouse, France, 4-7 Oct. 1989.
Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during
2 weeks of intense training. Abstract submitted to national meeting
of the Amer College of Sports Medicine, June 1998.
Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting
by chronic phosphatidylserine administration of the stress-induced
activation of the hypothalamo-pituitary-adrenal axis in healthy
men. Eur J Clin Pharm 43: 385388, 1992.
Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine
administration during two weeks of resistive exercise-induced
overtraining. Bio of Sport 15(3):135-44, 1998.
Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres
procyanidoliques sur le cobaye carence en vitamin c. Tavaux Originaux,
University of Bordeaux, 1976.
Masquelier, J. Action comparee de divers facteurs vitaminiques
p sur loxydation de lacide ascorbique par les ions
cuivriques. Bull. de la Societe de Chimie Biologique XXXIII (3-4)
1951. pp. 302-304.
Masquelier, J. Action comparee de divers facteurs vitaminiques
p sur lacide ascorbique-oxydase. Bull. de la Societe de
Chimie Biologique XXXIII (3,4) 1951. pp.304-306
Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G.,
Mishioka, I. Inhibitory effects of tannins on hyaluronidase
activation and on the degranulation from rat mesentery mast cells.
Chem. Pharm. Bull. 33(11)1985. 5079-5082.
Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J.
Histamine and acute haemorrhagic lesions in rat gastric
mucosa: prevention of stress ulcer formulation by (+)-catechin,
an inhibitor of specific histidine decarboxylase in vitro.
Dirkhauser Verlag,Vol. 7/1, 1977.
Pariente, J.J. Parientl-Amsellem, J. Les oedemes post-traumatoqies
chez le sportif: essai controle de lEndothelon. Actualite
Therapeutique 90(3) 2/11 1983 pp. 231-235.
Masquelier, J., et al. Flavonoids et Pycnogenols Int
J Vit Nut Res, (49)3:307-311, 1979.
Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem.
Toxicol. 25(2):135-9, 1987.
Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica
Report, 1971.
Laparra, J., et al., Acta Therapeutica, 4:233, 1978.
Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow
cells of the mouse with Pycnogenol. Cytotest Cell Research GmbH
& Co., projects 143010 & 143021; Feb. 1989.
Acute and chronic toxicity tests. International Bio-Research,
Inc., Hanover, Germany, 1967-1971.
Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content
in vegetable extracts to be used in the preparation of medicines.
Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990.