|
.
Flavay® scores the highest both as an
antioxidant and as a free radical scavenger.
This is precisely the free radical scavenging effect that Dr.
Masquelier described in U.S. Patent 4,698,360.
Independent Comparative Analysis
of Flavay®
With Grape Seed and Pine Bark Extracts
Flavay® is the authentic, standardized and isolated,
singular polyphenol complex defined, patented and perfected
by Dr. Jack Masquelier; proven safe and effective by numerous
human studies and used worldwide since 1950.
Dr. Masquelier's 1948 French Patent described a method to extract
the active principles in Flavay® from the bark of the
pinus Maritima. His 1970 French Patent described an
even more efficient extraction method of the active principles
from the seeds of the vitis vinifera grapes. On October
6, 1987 Dr. Masquelier was awarded U.S. Patent No. 4,698,360
to describe the proanthocyanidins in Flavay® for use as
a powerful antioxidant, "which has a radical scavenger
effect."
However, consumers need to know that the marketplace is full
of imitations, various “extracts” and derivative
forms of Dr. Masquelier’s scientifically proven and patented
complex. Unfortunately, many have used Dr. Masquelier’s
name and research in unauthorized ways to promote a myriad of
derivations. In fact, the other "leading brand" pine
bark extract, compared to Flavay® below, is an offshoot
derived from Dr. Masquelier's authentic work and products. But,
independent comparative testing demonstrates that the initial
qualifying research conducted on the authentic products may
not be automatically transferred to other commercial products.
As demonstrated below, Flavay® remains unsurpassed when
compared to other leading brands.
Independent Lab Report Results
and Conclusions
A highly qualified independent U.S. Laboratory performed five
analytical methods to put in qualitative perspective the differences
between Flavay® (extracted from grape seeds and pine bark)
and ten "grape seed extracts" currently on the market.
Later, a new study was performed to include the leading pine
bark extract (sample #14). Below are the results of these studies.
Electrochemical
Antioxidant Activity (ECA) Test:
The below ECA chromatograms represent a comparison of
the pine bark materials in Flavay® vs. the other leading
brand pine bark product. Test conditions and amounts of samples
were identical. Results are displayed on the same scale. Both
samples exhibit comparable positions in the peaks, confirming
that both samples originate from similar source plant materials.
However, note below, the other leading brand pine bark has
significantly lower amounts of antioxidant compounds per unit
weight. The rest of the sample is likely to be non-antioxidant
inert material.
The similar fingerprints indicate that the samples originate
from a similar source plant materials, but use different extraction
protocols. Flavay® scores the highest—demonstrating
its superior free radical scavenging effect.
Antioxidant Capacity (ACAP) Test:
The below ACAP-Trolox test was performed in addition to the
ECA test to establish a more balanced and certain assessment.
For the most reliable impression of the antioxidant capacity
of the products, two reproducible and controllable tests were
used to evaluate the antioxidant character of the samples. The
fluorescein-derivative antioxidant comparison with Trolox shows
that the tested leading brand pine bark-based extract (#14)
has little more than half the antioxidant capacity (55%) of
the pine bark materials in Flavay® (#6).
Relative
values of 10 grape seed samples compared to Flavay®;
and another leading pine bark-based product.
Highest Values Reached = 100% (1)
|
| Samples |
Antioxidant
Capacity
(ACAP) Trolox Equivalent |
Electrochemical
Antioxidant Activity
(ECA) Antioxidant "Versatility" |
| 1 |
grape
seed extract |
3% |
22% |
| 2 |
grape
seed extract |
66% |
2% |
| 3 |
grape
seed extract |
55% |
22% |
| 4 |
grape
seed extract |
34% |
41% |
| 5 |
Flavay®
(grape seed material) |
100% |
89% |
| 6 |
Flavay®
(pine bark material) |
100% |
76% |
| 7 |
Flavay®
(grape seed material) |
93% |
100% |
| 8 |
grape
seed extract |
24% |
15% |
| 9 |
grape
seed extract |
21% |
2% |
| 10 |
grape
seed extract |
76% |
74% |
| 11 |
grape
seed extract |
14% |
6% |
| 12 |
grape
seed extract |
76% |
33% |
| 13 |
grape
seed extract |
69% |
5% |
| 14 |
pine
bark extract |
55% |
23% |
SCIENTIFIC YARDSTICKS: ElectroChemical Activity
(ECA) represents the versatility and capacity of a substance
to "communicate" with another molecule by means of
exchanging electrons. Antioxidant Capacity (ACAP) is measured
by testing the material's capacity to neutralize the peroxyl
radical. The measurement is expressed in equivalents of a substance
called "Trolox," a soluble analogue of vitamin E.
The other leading pine bark extract (sample #14) is only 30%
as electrochemically active (ECA) as Flavay® pine bark
material. The pine bark-based sample #14 is only 23-26% as electrochemically
active as Flavay® grape seed material. The ACAP-Trolox
test indicates that the pine bark-based sample #14 has only
55% of the antioxidant capacity of Flavay® pine bark material.
It's important to
point out that sample #13 is aggressively marketed as a branded
"OPC" material. However, by means of Thin Layer Chromatography
(TLC) tests, no OPCs could be detected in the product. Furthermore,
sample #13 scores very low in electrochemical antioxidant capacity.
These tests demonstrate that Flavay®
scores the highest as an antioxidant and free radical
scavenger in both the ECA and the ACAP tests. This is precisely
the free radical scavenging effect that Dr. Masquelier invented
and claimed in U.S. Patent 4,698,360.
Quality and Purity Test
When dissolved in water or other specific test-liquids, the
limpidity (clearness, transparency) of the solutions provides
a simple and good, easy to check indicator of quality and purity.
Insolubles are an indicator of low quality and/or production
problems.
Percentages
of INSOLUBLES
Low
quality "OPC" materials only partially
dissolve,
indicating lack of quality and purity. |
|
| Quantity of sample |
pine bark
sample #14 |
Flavay®
pine bark |
|
| 2% in methanol |
0% |
0% |
| 1% in propanol-2 |
32.6% |
0% |
| 1% in ethanol |
2.7% |
0% |
|
|
Thus, Flavay® contains no insolubles. Each batch of Flavay®
materials, from pinus Maritima and vitis vinifera,
is tested by mixing a sample with methanol, propanol-2 and ethanol,
to check for insolubles in as broad range as possible. As you
can see from the chart above, pine bark sample #14 shows high
amounts of insolubles. Probably due to it's different extraction
process, pine bark sample #14 fails to measure up to the quality
and purity of Flavay®, which remains perfectly soluble
and limpid.
All of this confirms that the leading pine bark-based product
is in the mediocre grape seed extract category—both for
poor antioxidant performance and lack of purity.
Authentic vs. "Borrowed"
Science
Consumers need to know that the marketplace is full of imitations,
offshoots and derivatives of scientifically proven and patented
natural products. Those who are looking for a product that will
produce the proven results and not just the "claimed"
or "implied" results, want the authentic product that
was used in the actual scientific research. This is especially
important when you buy a product in the "grape seed extract"
and "pine bark extract" product category. It is practically
impossible for retailers and consumers to distinguish inferior
products from quality ones. As shown above, an independent test
found that no active OPCs could be detected in one leading American
brand of grape seed extract, even though it's labeled and aggressively
marketed as a branded OPC product. All of this proves that consumers
cannot be assured of the quality, bioavailability and safety
of the product.
| Flavay® is
the name you can trust for the precisely defined active
polyphenol complex patented and perfected by the inventor,
Dr. Jack Masquelier, validated by the French Ministry of
Health and documented by a library of research consisting
of many patents and hundreds of scientific papers, articles,
doctorate theses, lectures and presentations. For quality,
consistency, bioavailablity and safety, consumers may rely
upon Flavay®. |
 Flavay®
is precisely the same powerful antioxidant used
by Dr. Jack Masquelier in the actual experiments
by which he established
and patented the radical scavenger effect. |
|
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