A Completely Safe, Non-Drug,
Natural Approach
to Cardiovascular & Circulatory Health
Flavay® has been sold world-wide for cardiovascular health
and extensively tested in humans for more than 50 years. The
cardioprotective activity of Flavay® has been established
by many significant studies, demonstrating several important
ways in which Flavay® may mitigate the risk of heart attack
and stroke.
"Radical Scavenger Effect"
of Flavay
Protected by U.S. Patent No. 4,698,360
Patented and licensed in France for therapeutic uses, the U.S.
Government granted Dr. Masquelier a patent on October 6, 1987
which allows his proanthocyanidins complex, now sold as Flavay®,
to be used as an antioxidant here in the United States.
"[A] method for preventing and fighting
the harmful biological effects of free radicals
in the organism of warm blooded animals and more especially
human beings, namely cerebral involution, hypoxia following
atherosclerosis, cardiac or cerebral infarction, tumour
promotion, inflammation, ischaemia, alterations of the
synovial liquid, collagen degradation, among others.
The method consists in administering to said animals
and especially to human beings an amount, efficient
against said effects, of a plant extract with a proanthocyanidins
content which has a radical scavenger effect"—Dr.
Jack Masquelier, U.S. Patent No. 4,698,360.
Flavay® is the product—used in the actual experiments—by
which Dr. Jack Masquelier established and patented the "radical
scavenger effect."
Flavay®
Normalizes Reactivity ("Stickiness") of Blood Platelets
Flavay® protects the cardiovascular system in another
way. Considerable research demonstrates that Flavay® causes
blood platelets to return to their normal, smooth condition;
helping to keep the blood platelets from becoming "sticky"
and developing a tendency to unnecessarily clump together. Research
shows that Flavay® improves nitric oxide levels produced
by cells that line the arteries. Nitric oxide controls the muscles
surrounding the blood vessels and causes them to relax. At the
same time, nitric oxide causes blood platelets to return to
their normal, smooth condition. This can reduce the dangerous
formation of the blood clots which cause coronary thrombosis
resulting in myocardial infraction. Thus, we can see two important
ways in which Flavay® can help prevent the primary causes
of heart attack and stroke. But that isn’t all.
Flavay® Strengthens Blood
Vessels and Capillaries
Flavay® actually strengthens collagen in vascular walls
and capillaries (the smallest vessels), making the vessels stronger
and more elastic. Flavay® alters the membrane receptor
conformation of vascular walls, reducing the damaging effects
of the destructive enzymes elastase, collagenase and hyaluronidase,
by preventing them from attaching to and degrading vascular
walls. Flavay® further prevents destruction of vascular
walls by preventing the attachment to membranes of histamine
and hyaluronidase, both of which can decrease the strength of
vessel walls. Thus, in addition to preventing the root causes
of vessel occlusion, Flavay® strengthens vessels, thereby
reducing the risk of a rupture or hemorrhage, and helping to
prevent and relieve vascular fragility.
Inflammation as a Major Risk
in Cardiovascular Disease
The latest research shows that chronic inflammation from ordinary
bacterial infections plays a major role in coronary heart disease
and suggests that inflammation plays an even bigger role than
cholesterol as a trigger for heart attacks. Recent studies suggest
that biological markers of inflammation identify people at high
risk of developing the coronary heart disease, and an association
has been shown to exist between chronic infections, inflammatory
markers and coronary heart disease.
We now know that ordinary bacterial infections such as sinus
infections, urinary tract infections, bronchitis, periodontal
(gum) disease, and stomach ulcers are linked to heart disease.
Inflammation activates white blood cells, which use free radicals
to destroy bacteria and other foreign objects in the blood.
These white blood cells migrate to the arteries where some of
the free radicals leak out, oxidizing LDL and damaging the linings
of arteries. This process also elevates the C-reactive protein
(CRP) in the blood; a chemical necessary for fighting injury
and infection. Inflammation can be measured with a blood test
that checks for CRP.
An article published by the American Heart Association reported
that chronic infections may triple the risk of atherosclerosis,
even in persons that don't have the well-known risk factors
such as high blood pressure, obesity, diabetes or lack of exercise.
Flavay® is Particularly
Effective
Flavay® inhibits the release and synthesis of histamine
(which produces accelerated blood flow, dilates capillaries
and increases their permeability, thereby leaking plasma into
surrounding tissue), a key factor in the promotion of inflammation.
Studies demonstrate that the anti-histamine action of Flavay®
is obtained through inhibiting the activity of the enzyme histidine
decarboxylase. Studies have demonstrated that Flavay®
may lower the production of histamine with as much as 86% inhibition
of histidine decarboxylase. This is of particular interest in
protecting the cardiovascular system.
It's not surprising that inflammation can significantly increase
the risk of cardiovascular disease because inflammation is caused
by the overproduction of free radicals in a specific area of
the body. It is known that superoxide production is increased
in atherosclerosis and this oxidative stress contributes to
vascular damage. Superoxide is a free radical known to be involved
in inflammation. Flavay® is a powerful antioxidant that
readily quenches the superoxide free radicals and the other
free radicals produced by inflammation.
Free
Radicals in Cardiovascular Disease
Free radicals are involved in the progression of cardiovascular
disease in several different ways. Much of the damage that occurs
in both heart attacks and strokes is caused by reperfusion
injury: the burst of superoxide free radicals that flow
in as the blood flow resumes. The good news is that the nutrients
in Flavay® can protect tissues from this burst of superoxide
free radicals.
Flavay® has the greatest ability to control or destroy
free radicals. As a free radical fighter, Flavay® comes
to the aid of the body more quickly than other antioxidants,
reducing the potential for free radical damage. Flavay®
also possesses more reactive sites for neutralizing free radicals
than other known antioxidants. Furthermore, Flavay® permits
reactivity with both positively and negatively charged free
radical species. What this means is that Flavay® can “quench”
or “scavenge” (neutralize) a broad variety of free
radicals, including the superoxide free radical. Highly reactive
as an antioxidant in both lipid (fat) and aqueous (water) phases,
Flavay® neutralizes oxygen free radicals and is a valuable
protector of healthy cells in a variety of internal conditions.
This is a unique property among antioxidants, as most work either
in lipid or aqueous phases, but not both.
Flavay® is superior to other
antioxidants because its protective effects are multiplied in
the body: while it provides its own, powerful antioxidant protection,
it also supports the dynamic interplay between other antioxidants
in the body. Flavay's ability to “recycle,” or regenerate
vitamins C and E after they have quenched free radicals vastly
extends their unique antioxidant powers, helping the body to
maintain its synergistic antioxidant balance.
The
Good-Bad Free Radical: Nitric Oxide
Contemporary scientific studies have established another way
in which free radicals can promote atherosclerosis (hardening
of the arteries), and how one free radical in particular, nitric
oxide, plays a central role.
Nitric oxide (sometimes referred to as "NO") became
the subject of the prestigious Nobel Prize in Medicine when,
among other functions, it was determined that it was a powerful
vasodilator (the opening or widening of blood vessels which
leads to increased blood flow). Nitric oxide is produced in
the endothelial cells (cells that line the interior of blood
vessels) from arginine, and the nutrients in Flavay® act
on the endothelial cells to produce nitric oxide, which, in
turn, relaxes the blood vessels. This action counteracts the
vasoconstricting effects (the closing or narrowing of blood
vessels that leads to decreased blood flow) of the stress hormone
adrenaline and also diminishes the threat of platelets clumping.
Thus, nitric oxide is essential for normal blood circulation
as it controls the muscular tone of blood vessels and regulates
circulation and blood flow. However, excessive amounts of nitric
oxide can be deadly to the cardiovascular system and actually
contribute to heart disease and strokes, and many other
apparently different disorders (such as arthritis, asthma and
Parkinson's disease). High levels of nitric oxide can restrict
blood flow and promote production of more free radicals, including
the dangerous peroxynitrate. Altogether this shows that in order
to have good circulatory health, the body must activate the
optimum levels of nitric oxide—and research shows that
Flavay® can help regulate that balance by preventing the
overproduction of nitric oxide in the body.
Regulating Nitric Oxide: the
"Double-Edged Sword"
Scientific studies show that Flavay® helps to modulate
the effects of nitric oxide. This is very important because,
as discussed above, some nitric oxide is essential to good health
and too much can kill cells. Phrases such as "double-edged
sword" are frequently applied to nitric oxide in health
and disease. This emphasizes the importance of modulating this
free radical in the body. Research demonstrates that Flavay®
can help to maintain the optimal level of this free radical
by helping the body to produce adequate levels—and to neutralize
nitric oxide where it does harm.
Flavay® is Your Best Weapon
Against Toxic Free Radicals
Research also demonstrates that Flavay® can quench the
hydroxyl radical. This is extremely important. Of all the free
radicals formed in the body, the hydroxyl radical is the most
dangerous because it can directly attack DNA. As a free radical
scavenger, Flavay® is like an antioxidant prize fighter
that can successfully take on all challengers, big or small,
in any kind of weather.
Antioxidants:
The Sum is Greater Than the Parts
Until recently, scientists believed that each antioxidant worked
separately in the body, independently of the others. We now
know that isn't true. Current research demonstrates that antioxidants
work as a team, in sequence and in a complementary fashion,
even "recycling" each other for a more powerful, synergistic
effect. Harvard researchers found in a study of 87,000 female
nurses that a combination of antioxidant vitamins (beta-carotene
and vitamins C and E) provided far greater protection from cardiovascular
disease than the single antioxidants. Flavay® is a powerful
antioxidant that recycles and potentiates vitamin C, a key player
in the antioxidant army, and Flavay Plus®
thereby optimizes the synergy created by these antioxidant soldiers.
Synergistic Help for Cardiovascular
& Circulatory Health
Vitamin A (Beta-carotene and cartenoids):
Flavay Plus® contains the preferred form of Vitamin A,
beta-carotene (Betatene™). Beta-carotene is converted
by the body into vitamin A only as the body needs it and what
isn't converted remains as a powerful antioxidant, shown to
benefit the cardiovascular system. The beta-carotene in Flavay
Plus® is the highest quality, full-spectrum, patented Betatene™,
a complete array of plant-derived, antioxidant cartenoids: beta-carotene,
alpha-carotene, cryptoxanthin, zeaxanthin, lutein, and lycopene.
Vitamin C: Flavay Plus®
also contains vitamin C: water-soluble, a potent free radical
scavenger, recycles vitamin E, plays a primary role in the formation
of collagen, essential for vascular health and a strong immune
system. Controlled studies prove the contribution of vitamin
C in the manufacture of white blood cells and interferon.
In 1998, several well-controlled studies showed that vitamin
C enables the arterial system to expand and contract with youthful
elasticity. Cardiologists often prescribe nitroglycerine and
longer-acting nitrate drugs to dilate the coronary arteries
and relieve angina pain. Nitrate drugs not only improve coronary
blood flow, but they also lower the oxygen demand of the heart
by reducing peripheral vascular resistance.
Unfortunately, nitrate drugs also produce negative effects.
The main limiting factor to the nitrate drugs is tolerance,
i.e., the vascular system stops responding to the dilating effects
of the drugs and angina is no longer controlled. Nitrate drugs
may also cause a progressive weakening of the heart muscle cell's
ability to produce energy. When vitamin C is administered to
coronary artery disease patients, the vasodilating effects of
the nitrate drugs may be significantly prolonged and the energy
producing capacity of the cells maintained.
A double-blind study published in the Journal of the American
College of Cardiology (1998; Vol. 31(6), pp.1323-1329)
compared the effects of nitrate drugs in people receiving vitamin
C to a placebo group not receiving vitamin C. The doctors concluded
the study by stating "These results indicate that combination
therapy with vitamin C is potentially useful for preventing
the development of nitrate tolerance."
It's also important to note that Flavay®
dramatically extends the activity of vitamin C in the body.
Vitamin E: The body’s
principal fat-soluble antioxidant and must be obtained through
food or supplements. Much of the body’s free radical damage
occurs in fats and in fatty membranes of cells—exactly
where vitamin E protects the body. Many cardiologists now recommend
vitamin E supplementation.
Flavay Plus® uses only natural, cold-water dispersible
(dry) vitamin E because it is efficiently absorbed even when
taken on an empty stomach or with a low-fat meal. The other
forms of natural vitmain E, the non-cold water dispersible (oil)
forms, may be poorly absorbed unless taken with several grams
of fats or oils.
The National Academy of Science officially recognized natural
vitamin E (d-alpha) as twice as potent and retained twice as
well as synthetic (dl-alpha). This means twice as much natural
vitamin E reaches the blood and organs compared to synthetic
versions.
B-Vitamins: Flavay Plus®
is also formulated with many B-vitamins as they have been shown
to be vital for the cardiovascular system. Pyridoxine (vitamin
B-6) is needed for healthy blood and blood vessels. Many studies
indicate that vitamin B-6 helps prevent arteriosclerosis and
that low levels of vitamin B-6 may increase the risk of heart
attack. Vitamin B-6 is required by the body to turn iron into
hemoglobin, and to produce red blood cells and antibodies. In
a recent study of men and women from nine European countries,
researchers concluded that regardless of homocysteine levels,
a blood deficiency of vitamin B-6 was still "a very powerful
risk factor for heart disease and stroke."
Selenium:Flavay Plus® includes selenium,
as it is necessary for the body's production of glutathione
peroxidase, which destroys free radicals that trigger the formation
of plaque that clogs arteries leading to the heart. Also, human
platelets contain more selenium than any other tissue, suggesting
that the high concentration of selenium in platelets may prevent
blood clots. Selenium is also necessary for the body’s
production of glutathione (an antioxidant produced by the body
which protects the brain and nerve tissue from the harmful effects
of free radicals) and thioredoxin reductase which recycles vitamin
C. Selenium also has a synergistic effect with vitamin E, which
means that the two combined are more powerful than either alone.
Many Americans do not consume even the small RDA of selenium
in their diet.
Zinc: Zinc is a necessary
part of the body’s production of DHA and a constituent
of many vital enzymes, including superoxide dismutase (SOD),
which is a critical cellular antioxidant enzyme that is responsible
for mopping up peroxynitrate, the highly toxic free radical
produced in abundance in the normal course of immune system
battles (as in viral or bacterial infections) and plays a powerful
role in immune system inflammation. Together with the B vitamins,
zinc assists in the utilization of insulin and glucose. There
is a growing body of evidence to indicate that zinc is needed
for the proper maintenance of vitamin E levels in the blood
and aids in the absorption of vitamin A. Other important functions
of zinc include the promotion of glandular and reproductive
health; and there is strong evidence that zinc is essential
for cell repair and cell growth. There is evidence that zinc
levels fall after physical and mental stress. Flavay Plus®
uses zinc orotate, a high-quality, highly bioavailable form
of zinc.
Ginkgo biloba leaf: Used as
a medicinal treatment in China since 2800 B.C. for problems
related to brain function, heart disease, and other circulatory
disorders. Recent research has shown that ginkgo biloba extract
can help speed up recovery after a heart attack. Flavay Plus®
includes ginkgo biloba leaf extract that has been standardized
to 24% gingko flavone glycosides and 6% terpene lactones—the
clinically proven optimum rations used in the breakthrough studies
published in a mainstream medical journal.
Phosphatidyl serine:Flavay
Plus® is formulated with phosphatidyl serine (Leci-PS™),
a complex of amino and fatty acids extracted from soy lecithin,
which has proven to be a safe, potentially effective therapeutic
agent in treating memory deficit disorders. Phosphatidyl serine
has been the subject of many human clinical trials regarding
memory loss, mood, cognitive performance, learning ability and
stress.
Phosphatidyl serine is a phospholipid that is vital to brain
cell structure and function. Phospholipids are molecules containing
both amino and fatty acid components, which are found in every
cell membrane in our bodies. Phosphatidyl serine plays an important
role in our neurotransmitter systems, in metabolism levels of
the brain, and in maintaining nerve connections in the brain.
It appears to help reestablish the normal down-regulation of
cortisol secretion that is increased in chronically stressed
individuals.
Flavay Plus®
is a synergistic blend of phosphatidyl serine with Flavay®
and other antioxidants and
B vitamins because researchers show that phosphatidyl
serine works with other nutrients such as the B vitamins
and antioxidants.
Research has shown that phosphatidyl serine works to keep the
brain’s processes within normal limits, raising them when
they are low and lowering them when they are high. So phosphatidyl
serine boosts the weak stress response in the elderly person
and calms down exaggerated stress in the healthy young person.
Both physical and mental stressful conditions cause stress hormones
to be released into circulation, even in the young and healthy.
Phosphatidyl serine given to athletes prior to starting exercise
produced an impressive degree of down-regulation of the stress
hormones. Phosphatidyl serine may have the capacity to normalize
the stress-induced activation of the "fight or flight response."
In a double-blind, placebo-controlled study conducted in Italy,
phosphatidyl serine lowered stress hormone (cortisol) production
by 30 percent.
Two more recent placebo controlled studies confirmed the earlier
double-blind trials; young, university students experienced
significantly less stress from tests when they took phosphatidyl
serine (300 mg daily for 30 days), they stayed more clear-headed
and composed, and kept a more stable mood.
Flavay®: More Than 50
Years of Protection for Cardiovascular Health
Now available in the United States, Flavay®
is the actual polyphenol that has been licensed and sold in
France for cardiovascular benefits since 1950. And, Flavay
Plus® includes the highest-quality phosphatidyl serine
and other antioxidant nutrients and their co-factors in order
to offer you and your family with the best help that nutritional
science has to offer for confronting the stressful challenges
of living in today's world.
Statements made herein have not been
evaluated by the Food and Drug Administration. These products are not intended
to diagnose, treat, cure or prevent any disease.
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